The socio-economic and demographic changes that occurred over the past 50 years have dramatically expanded urban areas around the globe, thus bringing urban settlers in closer contact with nature.
Ticks have trespassed the limits of forests and grasslands to start inhabiting green spaces within metropolitan areas. Hence, the transmission of pathogens causing tick–bornediseases is an important threat to public health. Using volunteered tick bite reports collected by two Dutch initiatives, here we present a method to model tick bite risk using human exposure and tick hazard predictors.
Our method represents a step forward in risk modelling, since we combine a well-known ensemble learning method, Random Forest, with four count data models of the (zero-inflated) Poisson family.
This combination allows us to better model the disproportions inherent in the volunteered tick bite reports. Unlike canonical machine learning models, our method can capture the overdispersion or zero-inflation inherent in data, thus yielding tick bite risk predictions that resemble the original signal captured by volunteers. Mapping model predictions enables a visual inspection of the spatial patterns of tick bite risk in the Netherlands.
The Veluwe national park and the Utrechtse Heuvelrug forest, which are large forest-urban interfaces with several cities, are areas with high tick bite risk. This is expected, since these are popular places for recreation and tick activity is high in forests. However, our model can also predict high risk in less-intensively visited recreational areas, such as the patchy forests in the northeast of the country, the natural areas along the coastline, or some of the Frisian Islands. Our model could help public health specialists to design mitigation strategies for tick–bornediseases, and to target risky areas with awareness and prevention campaigns.
 Hemagglutinin Influenza A Virus H3N2 Wyoming 3/03) Recombinant (HEK) Hemagglutinin Influenza A Virus H3N2 Wyoming 3/03 |
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RP-643 |
Alpha Diagnostics |
2 ug |
EUR 164 |
 Antibody) Zinc Finger Protein 643 (ZNF643) Antibody |
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abx036524-100ug |
Abbexa |
100 ug |
EUR 391 |
|
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Zinc Finger Protein 643 (ZNF643) Antibody |
|
abx030432-400ul |
Abbexa |
400 ul |
EUR 523 |
|
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Zinc Finger Protein 643 (ZNF643) Antibody |
|
abx030432-80l |
Abbexa |
80 µl |
EUR 286 |
|
|
) Recombinant ErbB3 Protein (Ser 20-Thr 643) |
|
VAng-1508Lsx-200g |
Creative Biolabs |
200 µg |
EUR 3487 |
|
Description: Biotinylated Human ErbB3 (Her3) is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
Recombinant ErbB3 Protein (Ser 20-Thr 643) |
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VAng-1508Lsx-25g |
Creative Biolabs |
25 µg |
EUR 848 |
|
Description: Biotinylated Human ErbB3 (Her3) is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
 Antibody (internal region)) Polyclonal UNC5B (aa629-643) Antibody (internal region) |
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APR13924G |
Leading Biology |
0.1 mg |
EUR 484 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human UNC5B (aa629-643) (internal region). This antibody is tested and proven to work in the following applications: |
 Human Zinc finger protein 643, ZNF643 ELISA KIT |
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ELI-40775h |
Lifescience Market |
96 Tests |
EUR 824 |
 [His]) Human ErbB3 Protein (Ser 20-Thr 643) [His] |
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VAng-1512Lsx-100g |
Creative Biolabs |
100 µg |
EUR 765 |
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Description: Human ErbB3 (Her3), His tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1) |
Human ErbB3 Protein (Ser 20-Thr 643) [His] |
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VAng-1512Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 4009 |
|
Description: Human ErbB3 (Her3), His tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1) |
 [Strep]) Recombinant ErbB3 Protein (Ser 20-Thr 643) [Strep] |
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VAng-1513Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 6374 |
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Description: Human ErbB3 (Her3), Strep tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
Recombinant ErbB3 Protein (Ser 20-Thr 643) [Strep] |
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VAng-1513Lsx-250g |
Creative Biolabs |
250 µg |
EUR 2470 |
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Description: Human ErbB3 (Her3), Strep tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
Recombinant ErbB3 Protein (Ser 20-Thr 643) [Strep] |
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VAng-1513Lsx-25g |
Creative Biolabs |
25 µg |
EUR 765 |
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Description: Human ErbB3 (Her3), Strep tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
) Recombinant Mycoplasma Capricolum gyrB Protein (aa 1-643) |
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VAng-Lsx06200-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Mycoplasma Capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) DNA gyrase subunit B, recombinant protein. |
) Recombinant Mycobacterium Tuberculosis aftA Protein (aa 466-643) |
|
VAng-Yyj0006-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3689 |
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Description: Mycobacterium Tuberculosis Arabinofuranosyltransferase AftA (aftA), recombinant protein. |
) Recombinant Mycobacterium Leprae dxs Protein (aa 1-643) |
|
VAng-Yyj1920-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Mycobacterium Leprae 1-deoxy-D-xylulose-5-phosphate synthase (dxs), recombinant protein. |
) Recombinant Plasmodium Falciparum PF11_0090 Protein (aa 1-643) |
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VAng-Wyb6639-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Plasmodium Falciparum (isolate 3D7) Pescadillo homolog, partial, recombinant protein. |
) Recombinant Clostridium Botulinum CLD_0573 Protein (aa 1-643) |
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VAng-Lsx8042-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Clostridium Botulinum (strain Okra / Type B1) UPF0313 protein CLD_0573, recombinant protein. |
) Recombinant Caenorhabditis Elegans B0464.6 Protein (aa 1-643) |
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VAng-Ly3060-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Caenorhabditis Elegans uncharacterized protein B0464.6 (B0464.6), partial, recombination protein. |
) Recombinant Caenorhabditis Elegans C06E1.9 Protein (aa 1-643) |
|
VAng-Ly3118-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Caenorhabditis Elegans uncharacterized protein C06E1.9 (C06E1.9), partial, recombination protein. |
) Recombinant Haemophilus Influenzae thrS Protein (aa 1-643) |
|
VAng-Lsx03900-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Haemophilus Influenzae (strain PittEE) Threonine--tRNA ligase, recombinant protein. |
) Recombinant Pasteurella Multocida thrS Protein (aa 1-643) |
|
VAng-Cr7401-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Pasteurella Multocida (strain Pm70) Threonine--tRNA ligase (thrS), recombinant protein. |
) Recombinant Klebsiella Pneumoniae deaD Protein (aa 1-643) |
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VAng-Cr4749-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Klebsiella Pneumoniae (strain 342) Cold-shock DEAD box protein A (deaD), recombinant protein. |
) Recombinant Clostridium Perfringens thrS Protein (aa 1-643) |
|
VAng-Lsx00890-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Clostridium Perfringens Threonine--tRNA ligase, recombinant protein. |
 [Fc]) Recombinant Human ERBB3 Protein (aa 1-643) [Fc] |
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VAng-Cr3988-100g |
Creative Biolabs |
100 µg |
EUR 1687 |
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Description: Recombinant Human ERBB3 Protein (Met 1-Thr 643) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 95.4 kDa. (Accession ID: NP_001973.2) |
Recombinant Human ERBB3 Protein (aa 1-643) [Fc] |
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VAng-Cr3988-50g |
Creative Biolabs |
50 µg |
EUR 1027 |
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Description: Recombinant Human ERBB3 Protein (Met 1-Thr 643) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 95.4 kDa. (Accession ID: NP_001973.2) |
 [Fc]) Recombinant Rhesus ERBB3 Protein (aa 1-643) [Fc] |
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VAng-Cr3989-100g |
Creative Biolabs |
100 µg |
EUR 1687 |
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Description: Recombinant Rhesus ERBB3 Protein (Met 1-Thr 643) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 95.7 kDa. (Accession ID: XP_001113953.2) |
Recombinant Rhesus ERBB3 Protein (aa 1-643) [Fc] |
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VAng-Cr3989-50g |
Creative Biolabs |
50 µg |
EUR 1027 |
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Description: Recombinant Rhesus ERBB3 Protein (Met 1-Thr 643) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 95.7 kDa. (Accession ID: XP_001113953.2) |
) Recombinant Mycobacterium Bovis aftA Protein (aa 1-643) |
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VAng-Yyj3213-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Mycobacterium Bovis Arabinofuranosyltransferase AftA (aftA), recombinant protein. |
 Human pre-microRNA Expression Construct Lenti-miR-643 |
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PMIRH643PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
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 Polyclonal Antibody) Rabbit Anti-Human PRKCD (aa 643-647) Polyclonal Antibody |
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CPB-1170RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 Rabbit Anti-Human STAT6 Polyclonal Antibody, aa.643-647 |
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CPB-963RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 [Fc] (NP_001973.2)) Human ErbB3 Protein (Ser 20-Thr 643) [Fc] (NP_001973.2) |
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VAng-1510Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 4009 |
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Description: Human ErbB3 (Her3), Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
Human ErbB3 Protein (Ser 20-Thr 643) [Fc] (NP_001973.2) |
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VAng-1510Lsx-200g |
Creative Biolabs |
200 µg |
EUR 985 |
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Description: Human ErbB3 (Her3), Fc tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001973.2) |
-Aminocaproyl-MMAF ADC) Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAF ADC |
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ADC-W-643 |
Creative Biolabs |
1mg |
Ask for price |
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Description: This ADC product is comprised of an anti-ERBB2 antibody (trastuzumab) conjugated via a Aminocaproyl linker to MMAF |
 Anti-Hu CD361 APC |
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1A-643-T100 |
ExBio |
100 tests |
EUR 240 |
 Anti-Hu CD361 PE |
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1P-643-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD361 PE |
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1P-643-T100 |
ExBio |
100 tests |
EUR 240 |
 Anti-Hu CD361 Purified |
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11-643-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Hu CD361 Purified |
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11-643-C100 |
ExBio |
0.1 mg |
EUR 158 |
 [Fc] (P21860-1)) Human ErbB3 Protein (Ser 20-Thr 643) [Fc] (P21860-1) |
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VAng-1509Lsx-100g |
Creative Biolabs |
100 µg |
EUR 875 |
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Description: Human ErbB3 (Her3), Mouse IgG2a Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1) |
Human ErbB3 Protein (Ser 20-Thr 643) [Fc] (P21860-1) |
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VAng-1509Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 5494 |
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Description: Human ErbB3 (Her3), Mouse IgG2a Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1) |
 [His]) FITC-Labeled Human ErbB3 Protein (Ser 20-Thr 643) [His] |
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VAng-1511Lsx-200g |
Creative Biolabs |
200 µg |
EUR 5219 |
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Description: FITC-Labeled Human ErbB3 (Her3), His Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1) |
FITC-Labeled Human ErbB3 Protein (Ser 20-Thr 643) [His] |
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VAng-1511Lsx-25g |
Creative Biolabs |
25 µg |
EUR 848 |
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Description: FITC-Labeled Human ErbB3 (Her3), His Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1) |
 (strain Br4923)) Recombinant Mycobacterium Leprae dxs Protein (aa 1-643) (strain Br4923) |
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VAng-Yyj1921-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Mycobacterium Leprae (strain Br4923) 1-deoxy-D-xylulose-5-phosphate synthase (dxs), recombinant protein. |
 (strain SM101 / Type A)) Recombinant Clostridium Perfringens thrS Protein (aa 1-643) (strain SM101 / Type A) |
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VAng-Lsx01214-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Clostridium Perfringens (strain SM101 / Type A) Threonine--tRNA ligase, recombinant protein. |
 (strain ATCC 13124 / NCTC 8237 / Type A)) Recombinant Clostridium Perfringens thrS Protein (aa 1-643) (strain ATCC 13124 / NCTC 8237 / Type A) |
|
VAng-Lsx01215-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Clostridium Perfringens (strain ATCC 13124 / NCTC 8237 / Type A) Threonine--tRNA ligase, recombinant protein. |
