The following is a partial list of peer-reviewed publications based on work funded by the National Research Fund for Tick-Borne Diseases. Each of the publications in this list explicitly acknowledges NRFTD support.


Bockenstedt LK, Gonzalez DG, Haberman AM, Belperron AA. Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. J Clin Invest. 2012 Jul 2;122(7):2652-60.

Hawley KL, Olson CM Jr, Iglesias-Pedraz JM, et al. CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1228-32.

Hawley KL, Olson CM, Iglesias-Pedraz JM, et al. CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1228-32

Dunham-Ems SM, Caimano MJ, Eggers CH and Radolf JD. Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission. PLoS Pathog. 2012 February; 8(2): e1002532


Eggers CH, Caimano MJ, Malizia RA, et al. The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol. 2011 Nov;82(3):679-97.

Pappas CJ, Iyer R, Petzke MM, et al. Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog. 2011 July; 7(7): e1002102.

Caimano MJ, Kenedy MR, Kairu T, et al. The hybrid histidine kinase Hk1 Is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun. 2011 August; 79(8): 31173130.


Banik S, Terekhova D, Iyer R, et al. BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle. Infect Immun.  2010 Dec 20 [Epub ahead of print]

Barthold SA, Hodzic, Imai DM, et al. Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob Agents Chemother. 2010;54(2): 643-51.

Huang B, Troese MJ, Howe D, et al. Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane. Microb Pathog. 2010; 49(5): 273-84.

Huang B, Hubber A, McDonough JA, et al. The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes. Cell Microbiol. 2010; 12(9): 1292-307.

Huang B, Troese MY, Ye S, et al. Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane. Infect Immun. 2010; 78(5): 186473.

XU H, Caimano MJ, Lin T, et al. Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog. 2010; 6(9): e1001104.


Dunham-Ems SM, Caimano MJ, Pal U, et al. Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest. 2009; 119(12): 3652-65.

Grab DJ, Nyarko E, Nikolskaia OV, et al. Human brain microvascular endothelial cell traversal by Borrelia burgdorferi requires calcium signaling. Clin Microbiol Infect. 2009; 15(5): 422-6.

Saidac DS, Marras SAE, Parveen N. Detection and quantification of Lyme spirochetes using sensitive and specific molecular beacon probes. BMC Microbiol. 2009; 9: 43.

Troese MJ, Sarkar M, Galloway NL, et al. Differential expression and glycosylation of Anaplasma phagocytophilum major surface protein 2 paralogs during cultivation in Sialyl Lewis x-deficient host cells. Infect Immun. 2009; 77(5): 174656.

Troese MJ, Carlyon JA. Anaplasma phagocytophilum dense-cored organisms mediate cellular adherence through recognition of human P-selectin glycoprotein ligand 1. Infect Immun. 2009; 77(9): 401827.


Fallon BA, Keilp JG, Corbera KM, et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology. 2008; 70(13): 992-1003.

Hynes WL, Stokes MM, Hensley SM, et al. Using RNA interference to determine the role of varisin in the innate immune system of the hard tick Dermacentor variabilis (Acari: Ixodidae). Exp Appl Acarol. 2008; 46(1-4): 7-15

Kocan KM, de la Fuente J, Manzano-Roman R, et al. Silencing expression of the defensin, varisin, in male Dermacentor variabilis by RNA interference results in reduced Anaplasma marginale infections. Exp Appl Acarol. 2008;46(1-4):17-28.

Nelson CM, Herron MJ, Felsheim RF et al. Whole genome transcription profiling of Anaplasma phagocytophilum in human and tick host cells by tiling array analysis. BMC Genomics. 2008; 9: 364

Reneer DV, Troese MJ, Huang BA, et al. Anaplasma phagocytophilum PSGL-1-independent infection does not require Syk and leads to less efficient AnkA delivery. Cell Microbiol. 2008; 10(9): 1827-38.

Sarkar M, Troese MJ, Kearns SA, et al. Anaplasma phagocytophilum MSP2(P44)-18 predominates and is modified into multiple isoforms in human myeloid cells. Infect Immun. 2008; 76(5): 20908.

Wickramasekara S, Bunikis J, Wysoki V, Barbour AG. Identification of residual blood proteins in ticks by mass spectrometry proteomics. Emerg Infect Dis. 2008; 14(8): 1273-5.


Sarkar M, Reneer DV, Carlyon JA. Sialyl-Lewis x-independent infection of human myeloid cells by Anaplasma phagocytophilum strains HZ and HGE1. Infect Immun. 2007; 75(12): 5720-5.


Keilp JG, Corbera K, Slavov I, et al. WAIS-III and WMS-III performance in chronic Lyme disease. J Int Neuropsychol Soc. 2006; 12(1): 119-29.


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