Phenotypic characterization of encephalitis in the brains of goats experimentally infected with Spanish Goat Encephalitis Virus.

Spanish goat encephalitis virus (SGEV) is a novel tickborne flavivirus subtype, closely related to the flavivirus louping ill virus (LIV). SGEV caused a severe, acute and mortal neurological disease outbreak in northern Spain in a goat herd. In order to characterize the cell population in lesions and to determine the distribution of the inflammatory cells, central nervous system (CNS) samples of nine female Alpine goats challenged subcutaneously with SGEV over the right thorax behind the elbow were evaluated using immunohistochemistry (microglia-Iba1, T lymphocytes-CD3, B lymphocytes-CD20 and astrocytes-GFAP).

The number of microglia (37.8 %) and T lymphocytes (21.5 %) was greater than the number of B lymphocytes (16.8 %). Goats were classified into clusters based on the severity of histological lesions in CNS (A-mild to moderate lesions and B-severe lesions). Microglia was significantly more abundant than T and B lymphocytes in cluster B (severe lesions). The total area occupied by glial foci revealed that medulla oblongata and spinal cord were the most affected tissues.

Astrogliosis (GFAP+) was present in the majority of the CNS sections being near to the pial surface. The lesion predominance on the right side of the medulla oblongata, which could be associated to the site of challenge suggestive of neurotropic route was also statistically confirmed. Results suggest that the cellular immune response would be the most important response to the SGEV infection.

DiagNano Organic Gold Nanorods, diameter 40 nm, absorption max 650 nm

OR-40-650 1 mL
EUR 1022

DiagNano Amine Gold Nanorods, diameter 25 nm, absorption max 650 nm

RFA-25-650 1 mL
EUR 1022

DiagNano Amine Gold Nanorods, diameter 40 nm, absorption max 650 nm

RFA-40-650 1 mL
EUR 1022

DiagNano Biotin Gold Nanorods, diameter 25 nm, absorption max 650 nm

RFB-25-650 1 mL
EUR 1022

DiagNano Biotin Gold Nanorods, diameter 40 nm, absorption max 650 nm

RFB-40-650 1 mL
EUR 1022

DiagNano Carboxyl Gold Nanorods, diameter 25 nm, absorption max 650 nm

RFC-25-650 1 mL
EUR 1022

DiagNano Carboxyl Gold Nanorods, diameter 40 nm, absorption max 650 nm

RFC-40-650 1 mL
EUR 1022

DiagNano Methyl Gold Nanorods, diameter 40 nm, absorption max 650 nm

RFM-40-650 1 mL
EUR 1022

DiagNano NHS Gold Nanorods, diameter 25 nm, absorption max 650 nm

RFN-25-650 1 mL
EUR 1022

DiagNano NHS Gold Nanorods, diameter 40 nm, absorption max 650 nm

RFN-40-650 1 mL
EUR 1022

DiagNano Galactose conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RCG-25-650 1 mL
EUR 1022

DiagNano Galactose conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RCG-40-650 1 mL
EUR 1022

DiagNano NeutrAvidin conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RCN-25-650 1 mL
EUR 1022

DiagNano NeutrAvidin conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RCN-40-650 1 mL
EUR 1022

DiagNano Streptavidin conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RCS-25-650 1 mL
EUR 1022

DiagNano Fluorophore Labeled Gold Nanorods, diameter 25 nm, absorption max 650 nm

RFL-25-650 1 mL
EUR 1022

DiagNano Fluorophore Labeled Gold Nanorods, diameter 40 nm, absorption max 650 nm

RFL-40-650 1 mL
EUR 1022

DiagNano GSH conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RGS-40-650 1 mL
EUR 1022

DiagNano Protein A conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RCA-25-650 1 mL
EUR 1022

DiagNano Protein A conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RCA-40-650 1 mL
EUR 1022

DiagNano Gold Nanorods Covalent Conjugation Kit, diameter 25 nm, absorption max 650 nm

RCK-25-650 1 kit
EUR 1043

DiagNano Gold Nanorods Covalent Conjugation Kit, diameter 40 nm, absorption max 650 nm

RCK-40-650 1 kit
EUR 1043

DiagNano Anti-Mouse IgG conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RMG-25-650 1 mL
EUR 1022

DiagNano Anti-Mouse IgG conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RMG-40-650 1 mL
EUR 1022

DiagNano Anti-Rabbit IgG conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RRG-25-650 1 mL
EUR 1022

DiagNano Anti-Rabbit IgG conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RRG-40-650 1 mL
EUR 1022

DiagNano Anti-Human IgA conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RHA-25-650 1 mL
EUR 1022

DiagNano Anti-Human IgA conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RHA-40-650 1 mL
EUR 1022

DiagNano Anti-Human IgG conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RHG-25-650 1 mL
EUR 1022

DiagNano Anti-Human IgG conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RHG-40-650 1 mL
EUR 1022

DiagNano Anti-Human IgM conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm

RHM-25-650 1 mL
EUR 1022

DiagNano Anti-Human IgM conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm

RHM-40-650 1 mL
EUR 1022

MitoViewâ„¢ 650

9-70075
  • EUR 220.00
  • EUR 93.00
  • 20X50UG
  • 50UG
Description: Minimum order quantity: 1 unit of 50UG

Cyanine7 tetrazine, 100 mg

650 100 mg
EUR 1426

NucSpot Live 650

40082 50uL
EUR 355
Description: Minimum order quantity: 1 unit of 50uL

NucSpot Live 650

40082-T 10uL
EUR 116
Description: Minimum order quantity: 1 unit of 10uL

CytoTell™ Red 650

22255 500 Tests
EUR 132

CytoTell™ Red 650

22256 1000 Tests
EUR 176

AR (Ab-650) Antibody

CSB-PA227367-
EUR 335
Description: A polyclonal antibody against AR (Ab-650). Recognizes AR (Ab-650) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

AR (Ab-650) Antibody

CSB-PA227367-100ul 100ul
EUR 316
Description: A polyclonal antibody against AR (Ab-650). Recognizes AR (Ab-650) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Streptavidin Tag 650 50µg

ABP-NAB-SA650 50µg Ask for price

hsa-miR-650 Primers

MPH01952 150 ul / 10 uM
EUR 121

Polyclonal DGKZ Antibody (aa601-650)

APR03008G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DGKZ (aa601-650). This antibody is tested and proven to work in the following applications:

Androgen Receptor (Ab-650) Antibody

21105-100ul 100ul
EUR 252

Androgen Receptor (Ab-650) Antibody

21105-50ul 50ul
EUR 187

hsa-miR-650 miRNA Inhibitor

MIH03308 2 x 5.0 nmol
EUR 176

hsa-miR-650 miRNA Antagomir

MNH03308 2 x 5.0 nmol
EUR 329

Cal Red™ R525/650 AM

20590 1 mg
EUR 480

Cal Red™ R525/650 AM

20591 10x50 ug
EUR 350

Polyclonal DUSP16 / MKP7 Antibody (aa600-650)

AMM06968G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DUSP16 / MKP7 (aa600-650). This antibody is tested and proven to work in the following applications:

ASB-650 Antibody Conjugation Kit (OKCC00005)

OKCC00005 1 Unit
EUR 213
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

BDP 630/650 tetrazine, 1 mg

154 1 mg
EUR 108

BDP 630/650 azide, 1 mg

15430 1 mg
EUR 108

BDP 630/650 hydrazide, 1 mg

15470 1 mg
EUR 108

BDP 630/650 maleimide, 1 mg

15480 1 mg
EUR 108

BDP 630/650 amine, 1 mg

154C0 1 mg
EUR 108

BDP 650/665 azide, 1 mg

18430 1 mg
EUR 108

BDP 650/665 maleimide, 1 mg

18480 1 mg
EUR 108

BDP 630/650 tetrazine, 100 mg

654 100 mg
EUR 1426

BDP 630/650 hydrazide, 100 mg

65470 100 mg
EUR 839

BDP 630/650 maleimide, 100 mg

65480 100 mg
EUR 839

BDP 630/650 amine, 100 mg

654C0 100 mg
EUR 839

BDP 650/665 maleimide, 100 mg

68480 100 mg
EUR 839

BDP 630/650 tetrazine, 5 mg

254 5 mg
EUR 234

BDP 630/650 azide, 5 mg

25430 5 mg
EUR 182

BDP 630/650 hydrazide, 5 mg

25470 5 mg
EUR 182

BDP 630/650 maleimide, 5 mg

25480 5 mg
EUR 182

BDP 630/650 amine, 5 mg

254C0 5 mg
EUR 182

BDP 650/665 azide, 5 mg

28430 5 mg
EUR 182

BDP 650/665 maleimide, 5 mg

28480 5 mg
EUR 182

BDP 630/650 alkyne, 1 mg

A54B0 1 mg
EUR 108

BDP 650/665 alkyne, 1 mg

A84B0 1 mg
EUR 108

BDP 630/650 alkyne, 5 mg

B54B0 5 mg
EUR 182

BDP 650/665 alkyne, 5 mg

B84B0 5 mg
EUR 182

BDP 630/650 alkyne, 10 mg

C54B0 10 mg
EUR 245

BDP 650/665 alkyne, 10 mg

C84B0 10 mg
EUR 245

BDP 630/650 alkyne, 25 mg

D54B0 25 mg
EUR 316

BDP 650/665 alkyne, 25 mg

D84B0 25 mg
EUR 316

BDP 630/650 alkyne, 50 mg

E54B0 50 mg
EUR 501

BDP 650/665 alkyne, 50 mg

E84B0 50 mg
EUR 501

BDP 630/650 alkyne, 100 mg

F54B0 100 mg
EUR 839

BDP 650/665 alkyne, 100 mg

F84B0 100 mg
EUR 839

BDP 630/650 azide, 10 mg

35430 10 mg
EUR 245

BDP 650/665 azide, 10 mg

38430 10 mg
EUR 245

BDP 630/650 tetrazine, 25 mg

454 25 mg
EUR 513

BDP 630/650 azide, 25 mg

45430 25 mg
EUR 316

BDP 630/650 hydrazide, 25 mg

45470 25 mg
EUR 316

BDP 630/650 maleimide, 25 mg

45480 25 mg
EUR 316

BDP 630/650 amine, 25 mg

454C0 25 mg
EUR 316

BDP 650/665 azide, 25 mg

48430 25 mg
EUR 316

BDP 650/665 maleimide, 25 mg

48480 25 mg
EUR 316

BDP 630/650 tetrazine, 50 mg

554 50 mg
EUR 921

BDP 630/650 azide, 50 mg

55430 50 mg
EUR 501

BDP 630/650 hydrazide, 50 mg

55470 50 mg
EUR 501

BDP 630/650 maleimide, 50 mg

55480 50 mg
EUR 501

BDP 630/650 amine, 50 mg

554C0 50 mg
EUR 501

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