Spanish goat encephalitis virus (SGEV) is a novel tick–borne flavivirus subtype, closely related to the flavivirus louping ill virus (LIV). SGEV caused a severe, acute and mortal neurological disease outbreak in northern Spain in a goat herd. In order to characterize the cell population in lesions and to determine the distribution of the inflammatory cells, central nervous system (CNS) samples of nine female Alpine goats challenged subcutaneously with SGEV over the right thorax behind the elbow were evaluated using immunohistochemistry (microglia-Iba1, T lymphocytes-CD3, B lymphocytes-CD20 and astrocytes-GFAP).
The number of microglia (37.8 %) and T lymphocytes (21.5 %) was greater than the number of B lymphocytes (16.8 %). Goats were classified into clusters based on the severity of histological lesions in CNS (A-mild to moderate lesions and B-severe lesions). Microglia was significantly more abundant than T and B lymphocytes in cluster B (severe lesions). The total area occupied by glial foci revealed that medulla oblongata and spinal cord were the most affected tissues.
Astrogliosis (GFAP+) was present in the majority of the CNS sections being near to the pial surface. The lesion predominance on the right side of the medulla oblongata, which could be associated to the site of challenge suggestive of neurotropic route was also statistically confirmed. Results suggest that the cellular immune response would be the most important response to the SGEV infection.
DiagNano Organic Gold Nanorods, diameter 40 nm, absorption max 650 nm |
OR-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Amine Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RFA-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Amine Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RFA-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Biotin Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RFB-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Biotin Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RFB-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Carboxyl Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RFC-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Carboxyl Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RFC-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Methyl Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RFM-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano NHS Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RFN-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano NHS Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RFN-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Galactose conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RCG-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Galactose conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RCG-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano NeutrAvidin conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RCN-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano NeutrAvidin conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RCN-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Streptavidin conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RCS-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Fluorophore Labeled Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RFL-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Fluorophore Labeled Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RFL-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano GSH conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RGS-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Protein A conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RCA-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Protein A conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RCA-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Gold Nanorods Covalent Conjugation Kit, diameter 25 nm, absorption max 650 nm |
RCK-25-650 |
Creative Diagnostics |
1 kit |
EUR 1043 |
DiagNano Gold Nanorods Covalent Conjugation Kit, diameter 40 nm, absorption max 650 nm |
RCK-40-650 |
Creative Diagnostics |
1 kit |
EUR 1043 |
DiagNano Anti-Mouse IgG conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RMG-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Mouse IgG conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RMG-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Rabbit IgG conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RRG-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Rabbit IgG conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RRG-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Human IgA conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RHA-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Human IgA conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RHA-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Human IgG conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RHG-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Human IgG conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RHG-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Human IgM conjugated Gold Nanorods, diameter 25 nm, absorption max 650 nm |
RHM-25-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
DiagNano Anti-Human IgM conjugated Gold Nanorods, diameter 40 nm, absorption max 650 nm |
RHM-40-650 |
Creative Diagnostics |
1 mL |
EUR 1022 |
MitoViewâ„¢ 650 |
9-70075 |
Biotium |
|
|
Description: Minimum order quantity: 1 unit of 50UG |
Cyanine7 tetrazine, 100 mg |
650 |
Lumiprobe |
100 mg |
EUR 1426 |
NucSpot Live 650 |
40082 |
Biotium |
50uL |
EUR 355 |
Description: Minimum order quantity: 1 unit of 50uL |
NucSpot Live 650 |
40082-T |
Biotium |
10uL |
EUR 116 |
Description: Minimum order quantity: 1 unit of 10uL |
AR (Ab-650) Antibody |
CSB-PA227367- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against AR (Ab-650). Recognizes AR (Ab-650) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
AR (Ab-650) Antibody |
CSB-PA227367-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against AR (Ab-650). Recognizes AR (Ab-650) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
Streptavidin Tag 650 50µg |
ABP-NAB-SA650 |
Allele Biotech |
50µg |
Ask for price |
|
hsa-miR-650 Primers |
MPH01952 |
ABM |
150 ul / 10 uM |
EUR 121 |
Polyclonal DGKZ Antibody (aa601-650) |
APR03008G |
Leading Biology |
0.05ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DGKZ (aa601-650). This antibody is tested and proven to work in the following applications: |
Androgen Receptor (Ab-650) Antibody |
21105-100ul |
SAB |
100ul |
EUR 252 |
Androgen Receptor (Ab-650) Antibody |
21105-50ul |
SAB |
50ul |
EUR 187 |
hsa-miR-650 miRNA Inhibitor |
MIH03308 |
ABM |
2 x 5.0 nmol |
EUR 176 |
hsa-miR-650 miRNA Antagomir |
MNH03308 |
ABM |
2 x 5.0 nmol |
EUR 329 |
Polyclonal DUSP16 / MKP7 Antibody (aa600-650) |
AMM06968G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DUSP16 / MKP7 (aa600-650). This antibody is tested and proven to work in the following applications: |
ASB-650 Antibody Conjugation Kit (OKCC00005) |
OKCC00005 |
Aviva Systems Biology |
1 Unit |
EUR 213 |
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity: |
BDP 630/650 tetrazine, 1 mg |
154 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 630/650 azide, 1 mg |
15430 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 630/650 hydrazide, 1 mg |
15470 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 630/650 maleimide, 1 mg |
15480 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 630/650 amine, 1 mg |
154C0 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 650/665 azide, 1 mg |
18430 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 650/665 maleimide, 1 mg |
18480 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 630/650 tetrazine, 100 mg |
654 |
Lumiprobe |
100 mg |
EUR 1426 |
BDP 630/650 hydrazide, 100 mg |
65470 |
Lumiprobe |
100 mg |
EUR 839 |
BDP 630/650 maleimide, 100 mg |
65480 |
Lumiprobe |
100 mg |
EUR 839 |
BDP 630/650 amine, 100 mg |
654C0 |
Lumiprobe |
100 mg |
EUR 839 |
BDP 650/665 maleimide, 100 mg |
68480 |
Lumiprobe |
100 mg |
EUR 839 |
BDP 630/650 tetrazine, 5 mg |
254 |
Lumiprobe |
5 mg |
EUR 234 |
BDP 630/650 azide, 5 mg |
25430 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 630/650 hydrazide, 5 mg |
25470 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 630/650 maleimide, 5 mg |
25480 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 630/650 amine, 5 mg |
254C0 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 650/665 azide, 5 mg |
28430 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 650/665 maleimide, 5 mg |
28480 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 630/650 alkyne, 1 mg |
A54B0 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 650/665 alkyne, 1 mg |
A84B0 |
Lumiprobe |
1 mg |
EUR 108 |
BDP 630/650 alkyne, 5 mg |
B54B0 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 650/665 alkyne, 5 mg |
B84B0 |
Lumiprobe |
5 mg |
EUR 182 |
BDP 630/650 alkyne, 10 mg |
C54B0 |
Lumiprobe |
10 mg |
EUR 245 |
BDP 650/665 alkyne, 10 mg |
C84B0 |
Lumiprobe |
10 mg |
EUR 245 |
BDP 630/650 alkyne, 25 mg |
D54B0 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 650/665 alkyne, 25 mg |
D84B0 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 630/650 alkyne, 50 mg |
E54B0 |
Lumiprobe |
50 mg |
EUR 501 |
BDP 650/665 alkyne, 50 mg |
E84B0 |
Lumiprobe |
50 mg |
EUR 501 |
BDP 630/650 alkyne, 100 mg |
F54B0 |
Lumiprobe |
100 mg |
EUR 839 |
BDP 650/665 alkyne, 100 mg |
F84B0 |
Lumiprobe |
100 mg |
EUR 839 |
BDP 630/650 azide, 10 mg |
35430 |
Lumiprobe |
10 mg |
EUR 245 |
BDP 650/665 azide, 10 mg |
38430 |
Lumiprobe |
10 mg |
EUR 245 |
BDP 630/650 tetrazine, 25 mg |
454 |
Lumiprobe |
25 mg |
EUR 513 |
BDP 630/650 azide, 25 mg |
45430 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 630/650 hydrazide, 25 mg |
45470 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 630/650 maleimide, 25 mg |
45480 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 630/650 amine, 25 mg |
454C0 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 650/665 azide, 25 mg |
48430 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 650/665 maleimide, 25 mg |
48480 |
Lumiprobe |
25 mg |
EUR 316 |
BDP 630/650 tetrazine, 50 mg |
554 |
Lumiprobe |
50 mg |
EUR 921 |
BDP 630/650 azide, 50 mg |
55430 |
Lumiprobe |
50 mg |
EUR 501 |
BDP 630/650 hydrazide, 50 mg |
55470 |
Lumiprobe |
50 mg |
EUR 501 |
BDP 630/650 maleimide, 50 mg |
55480 |
Lumiprobe |
50 mg |
EUR 501 |
BDP 630/650 amine, 50 mg |
554C0 |
Lumiprobe |
50 mg |
EUR 501 |